Association of Serum Vitamin D with the Risk of Incident Dementia and Subclinical Indices of Brain Aging: The Framingham Heart Study
Identifieur interne : 002329 ( Main/Exploration ); précédent : 002328; suivant : 002330Association of Serum Vitamin D with the Risk of Incident Dementia and Subclinical Indices of Brain Aging: The Framingham Heart Study
Auteurs : Ioannis Karakis [États-Unis] ; Matthew P. Pase [États-Unis, Australie] ; Alexa Beiser [États-Unis] ; Sarah L. Booth [États-Unis] ; Paul F. Jacques [États-Unis] ; Gail Rogers [États-Unis] ; Charles Decarli [États-Unis] ; Ramachandran S. Vasan [États-Unis] ; Thomas J. Wang [États-Unis] ; Jayandra J. Himali [États-Unis] ; Cedric Annweiler [France, Canada] ; Sudha Seshadri [États-Unis]Source :
- Journal of Alzheimer's disease : JAD [ 1387-2877 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Analyse de régression, Analyse multivariée, Démence (imagerie diagnostique), Démence (sang), Démence (épidémiologie), Encéphale (imagerie diagnostique), Femelle, Humains, Imagerie par résonance magnétique, Incidence, Mâle, Risque, Sensibilité et spécificité, Tests neuropsychologiques, Vieillissement (anatomopathologie), Vieillissement (sang), Vitamine D (sang), Études de cohortes.
- MESH :
- anatomopathologie : Vieillissement.
- imagerie diagnostique : Démence, Encéphale.
- sang : Démence, Vieillissement, Vitamine D.
- épidémiologie : Démence.
- Adulte, Adulte d'âge moyen, Analyse de régression, Analyse multivariée, Femelle, Humains, Imagerie par résonance magnétique, Incidence, Mâle, Risque, Sensibilité et spécificité, Tests neuropsychologiques, Études de cohortes.
English descriptors
- KwdEn :
- Adult, Aging (blood), Aging (pathology), Brain (diagnostic imaging), Cohort Studies, Dementia (blood), Dementia (diagnostic imaging), Dementia (epidemiology), Female, Humans, Incidence, Magnetic Resonance Imaging, Male, Middle Aged, Multivariate Analysis, Neuropsychological Tests, Regression Analysis, Risk, Sensitivity and Specificity, Vitamin D (blood).
- MESH :
- chemical , blood : Vitamin D.
- blood : Aging, Dementia.
- diagnostic imaging : Brain, Dementia.
- epidemiology : Dementia.
- pathology : Aging.
- Adult, Cohort Studies, Female, Humans, Incidence, Magnetic Resonance Imaging, Male, Middle Aged, Multivariate Analysis, Neuropsychological Tests, Regression Analysis, Risk, Sensitivity and Specificity.
Abstract
Identifying nutrition- and lifestyle-based risk factors for cognitive impairment and dementia may aid future primary prevention efforts.
We aimed to examine the association of serum vitamin D levels with incident all-cause dementia, clinically characterized Alzheimer’s disease (AD), MRI markers of brain aging, and neuropsychological function.
Framingham Heart Study participants had baseline serum 25-hydroxyvitamin D (25(OH)D) concentrations measured between 1986 and 2001. Vitamin D status was considered both as a continuous variable and dichotomized as deficient (<10 ng/mL), or at the cohort-specific 20th and 80th percentiles. Vitamin D was related to the 9-year risk of incident dementia (
In adjusted models, participants with vitamin D deficiency (
In this large community-based sample, low 25(OH)D concentrations were associated with smaller hippocampal volume and poorer neuropsychological function.
Url:
DOI: 10.3233/JAD-150991
PubMed: 26890771
PubMed Central: 4911705
Affiliations:
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Le document en format XML
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<author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name>
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<affiliation wicri:level="2"><nlm:aff id="A3">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Alzheimer's disease : JAD</title>
<idno type="ISSN">1387-2877</idno>
<idno type="eISSN">1875-8908</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aging (blood)</term>
<term>Aging (pathology)</term>
<term>Brain (diagnostic imaging)</term>
<term>Cohort Studies</term>
<term>Dementia (blood)</term>
<term>Dementia (diagnostic imaging)</term>
<term>Dementia (epidemiology)</term>
<term>Female</term>
<term>Humans</term>
<term>Incidence</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multivariate Analysis</term>
<term>Neuropsychological Tests</term>
<term>Regression Analysis</term>
<term>Risk</term>
<term>Sensitivity and Specificity</term>
<term>Vitamin D (blood)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de régression</term>
<term>Analyse multivariée</term>
<term>Démence (imagerie diagnostique)</term>
<term>Démence (sang)</term>
<term>Démence (épidémiologie)</term>
<term>Encéphale (imagerie diagnostique)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Imagerie par résonance magnétique</term>
<term>Incidence</term>
<term>Mâle</term>
<term>Risque</term>
<term>Sensibilité et spécificité</term>
<term>Tests neuropsychologiques</term>
<term>Vieillissement (anatomopathologie)</term>
<term>Vieillissement (sang)</term>
<term>Vitamine D (sang)</term>
<term>Études de cohortes</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Vitamin D</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Vieillissement</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Aging</term>
<term>Dementia</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Brain</term>
<term>Dementia</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Dementia</term>
</keywords>
<keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Démence</term>
<term>Encéphale</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Aging</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Démence</term>
<term>Vieillissement</term>
<term>Vitamine D</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Démence</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Cohort Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Incidence</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multivariate Analysis</term>
<term>Neuropsychological Tests</term>
<term>Regression Analysis</term>
<term>Risk</term>
<term>Sensitivity and Specificity</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de régression</term>
<term>Analyse multivariée</term>
<term>Femelle</term>
<term>Humains</term>
<term>Imagerie par résonance magnétique</term>
<term>Incidence</term>
<term>Mâle</term>
<term>Risque</term>
<term>Sensibilité et spécificité</term>
<term>Tests neuropsychologiques</term>
<term>Études de cohortes</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">Identifying nutrition- and lifestyle-based risk factors for cognitive impairment and dementia may aid future primary prevention efforts.</p>
</sec>
<sec id="S2"><title>Objective</title>
<p id="P2">We aimed to examine the association of serum vitamin D levels with incident all-cause dementia, clinically characterized Alzheimer’s disease (AD), MRI markers of brain aging, and neuropsychological function.</p>
</sec>
<sec id="S3"><title>Methods</title>
<p id="P3">Framingham Heart Study participants had baseline serum 25-hydroxyvitamin D (25(OH)D) concentrations measured between 1986 and 2001. Vitamin D status was considered both as a continuous variable and dichotomized as deficient (<10 ng/mL), or at the cohort-specific 20th and 80th percentiles. Vitamin D was related to the 9-year risk of incident dementia (<italic>n</italic>
= 1663), multiple neuropsychological tests (<italic>n</italic>
= 1291) and MRI markers of brain volume, white matter hyperintensities and silent cerebral infarcts (<italic>n</italic>
= 1139).</p>
</sec>
<sec id="S4"><title>Results</title>
<p id="P4">In adjusted models, participants with vitamin D deficiency (<italic>n</italic>
= 104, 8% of the cognitive sample) displayed poorer performance on Trail Making B-A (β = −0.03 to −0.05 ±0.02) and the Hooper Visual Organization Test (β = −0.09 to −0.12 ±0.05), indicating poorer executive function, processing speed, and visuo-perceptual skills. These associations remained when vitamin D was examined as a continuous variable or dichotomized at the cohort specific 20th percentile. Vitamin D deficiency was also associated with lower hippocampal volumes (β = −0.01 ±0.01) but not total brain volume, white matter hyperintensities, or silent brain infarcts. No association was found between vitamin D deficiency and incident all-cause dementia or clinically characterized AD.</p>
</sec>
<sec id="S5"><title>Conclusions</title>
<p id="P5">In this large community-based sample, low 25(OH)D concentrations were associated with smaller hippocampal volume and poorer neuropsychological function.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Canada</li>
<li>France</li>
<li>États-Unis</li>
</country>
<region><li>Californie</li>
<li>Géorgie (États-Unis)</li>
<li>Massachusetts</li>
<li>Tennessee</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Karakis, Ioannis" sort="Karakis, Ioannis" uniqKey="Karakis I" first="Ioannis" last="Karakis">Ioannis Karakis</name>
</region>
<name sortKey="Beiser, Alexa" sort="Beiser, Alexa" uniqKey="Beiser A" first="Alexa" last="Beiser">Alexa Beiser</name>
<name sortKey="Beiser, Alexa" sort="Beiser, Alexa" uniqKey="Beiser A" first="Alexa" last="Beiser">Alexa Beiser</name>
<name sortKey="Beiser, Alexa" sort="Beiser, Alexa" uniqKey="Beiser A" first="Alexa" last="Beiser">Alexa Beiser</name>
<name sortKey="Booth, Sarah L" sort="Booth, Sarah L" uniqKey="Booth S" first="Sarah L." last="Booth">Sarah L. Booth</name>
<name sortKey="Decarli, Charles" sort="Decarli, Charles" uniqKey="Decarli C" first="Charles" last="Decarli">Charles Decarli</name>
<name sortKey="Himali, Jayandra J" sort="Himali, Jayandra J" uniqKey="Himali J" first="Jayandra J." last="Himali">Jayandra J. Himali</name>
<name sortKey="Himali, Jayandra J" sort="Himali, Jayandra J" uniqKey="Himali J" first="Jayandra J." last="Himali">Jayandra J. Himali</name>
<name sortKey="Jacques, Paul F" sort="Jacques, Paul F" uniqKey="Jacques P" first="Paul F." last="Jacques">Paul F. Jacques</name>
<name sortKey="Pase, Matthew P" sort="Pase, Matthew P" uniqKey="Pase M" first="Matthew P." last="Pase">Matthew P. Pase</name>
<name sortKey="Pase, Matthew P" sort="Pase, Matthew P" uniqKey="Pase M" first="Matthew P." last="Pase">Matthew P. Pase</name>
<name sortKey="Rogers, Gail" sort="Rogers, Gail" uniqKey="Rogers G" first="Gail" last="Rogers">Gail Rogers</name>
<name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name>
<name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name>
<name sortKey="Vasan, Ramachandran S" sort="Vasan, Ramachandran S" uniqKey="Vasan R" first="Ramachandran S." last="Vasan">Ramachandran S. Vasan</name>
<name sortKey="Wang, Thomas J" sort="Wang, Thomas J" uniqKey="Wang T" first="Thomas J." last="Wang">Thomas J. Wang</name>
</country>
<country name="Australie"><noRegion><name sortKey="Pase, Matthew P" sort="Pase, Matthew P" uniqKey="Pase M" first="Matthew P." last="Pase">Matthew P. Pase</name>
</noRegion>
</country>
<country name="France"><noRegion><name sortKey="Annweiler, Cedric" sort="Annweiler, Cedric" uniqKey="Annweiler C" first="Cedric" last="Annweiler">Cedric Annweiler</name>
</noRegion>
</country>
<country name="Canada"><noRegion><name sortKey="Annweiler, Cedric" sort="Annweiler, Cedric" uniqKey="Annweiler C" first="Cedric" last="Annweiler">Cedric Annweiler</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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